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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . November 15th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

AIDS/HIV Therapy - Pharmacokinetic properties of reverse transcriptase inhibitors reviewed

Bacteriology - Antibacterial activity of cloth functionalized

Community-Acquired Infection - Impact of regular attendance by infectious disease specialists determined

Noscomial Pathogens - Incidence of noscomial pathogens determined for 38 centers from 17 countries

Trichomoniasis - Dicationic compounds effective against Trichomonas vaginalis identified

Adenovirus - Genome of human adenovirus serotype 1 sequenced and annotated

Anthrax - Anthrax vaccine award rescheduled

Antibiotic Resistance - License agreement forged to compounds that fight antibiotic-resistant infections

Antibiotics - Generic drug developer gets U.S. FDA approval for cefuroxime axetil tablets

Antimicrobial Resistance - Antimicrobial resistance takes a large toll in developing countries

Aspergillosis - Liver iron overload after SCT associated with invasive aspergillosis

Avian Influenza - Thailand's 12th human death from bird flu

BK Virus - Full-length BK virus sequence analysis shows high intrastrain genetic diversity

Bacteriology -  S. typhimurium recognizes a distinct form of bacterial quorum-sensing signal

Bacteriology - Biofuel cells select for microbial consortia that self-mediate electron transfer

Bacteriology - Kimchi-derived plasmid pC7 characterized

Bioterrorism - New microarray test funded by NIH

Blood Safety - Experts to check on possible spread of syphilis through donated blood

Bone Marrow Transplantation - B-cell depletion in BM transplant correlates with significantly lower EBV load

Burns - Serum levels of CD38 in burn patients are markers for lymphocyte activation

Chikungunya Virus - Chikungunya virus epidemic reemerged in Democratic Republic of the Congo

Cystic Fibrosis - Decreased lactoferrin activity implicated in P. aeruginosa infection in CF

Dengue Virus - Dengue-2 genotype IV is the predominant and circulating strain in northern India

Drug Development - Novel thiosemicarbazones have potent anti-Trypanosoma activity

Escherichia Coli - Pathogen distribution model developed for E. coli O157:H7 in ground beef

Finance - Biopharmaceutical company completes equity placement

Finance - Biotech completes new financing

Fitness & Wellness - Parishioners in Vermont urged to end sharing chalice, shaking hands to stop flu

Flu Vaccine - Illinois negotiating purchase of flu vaccine in Europe

Food Safety - Antimicrobial resistance risk assessment in food safety reviewed

Foot and Mouth Disease - Presence of viral RNA indicates viral persistence in foot-and-mouth disease

HIV/AIDS Coinfection - High HTLV-1 prevalence in immigrant male-to-female transsexual HIV+ sex workers

HIV/AIDS Drug Resistance - HIV-1 resistance to enfuvirtide characterized by very low genetic barrier

HIV/AIDS Infection - Alcohol abuse associated with increased sexual risk for HIV infection in Africa

HIV/AIDS Prevention - Prevention program demonstrates change in HIV/AIDS/STI knowledge in Sierra Leone

HIV/AIDS Research - HIV-1 Tat regulates SOD2 basal promoter by altering Sp1/Sp3 binding activity

HIV/AIDS Research - HIV-1 compartmentalizes in diverse leukocyte populations during HAART

HIV/AIDS Research - Macaques infected with SIV chimera containing HIV-1 RT useful for NNRTI studies

HIV/AIDS Research - Model developed to study function of HIV-infected monocyte-derived macrophages

HIV/AIDS Research - Novel assay identifies entry inhibitors that block HIV-1 gp120 binding to CCR5

HIV/AIDS Research - Proviral clone replicates the same as its parental HIV-1 group O isolate

HIV/AIDS Risk Factor - HSV-2 is key risk factor in promoting HIV transmission

HIV/AIDS Therapy - Antiretroviral drug HpAZT is less cytotoxic than AZT

HIV/AIDS Therapy - Development of HIV therapies GS 9005 and GS 7340 discontinued

HIV/AIDS Therapy - FDA grants traditional approval for fusion inhibitor for HIV treatment

HIV/AIDS Therapy - HIV-inhibitory cyclic depsipeptide isolated from marine sponge

HIV/AIDS Therapy - Infectious Diseases Institute opens in Uganda to care for people with HIV/AIDS

HIV/AIDS Therapy - Initial indinivir dose should based on patient sex and ritonavir intake

HIV/AIDS Therapy - K65R/Q151M mutations frequently selected during NRTI exposure in HIV-2 infection

HIV/AIDS Therapy - NNRT analog has novel mechanism for HIV RT inhibition

HIV/AIDS Therapy - Novel nonnucleoside HIV-1 RT inhibitors have minimal cytotoxicity

HIV/AIDS Therapy - Synthetic batzelladine analogues inhibit HIV-1 envelope-mediated fusion

HIV/AIDS Vertical Transmission - HIV subtype C preferentially transmitted in utero over subtypes A or D

HIV/AIDS Viral Load - HIV RNA levels differ by sex/risk group/age before ART initiation

HIV/AIDS-Coinfection - HIV-1 transactivated by Mycobacterium tuberculosis-infected macrophages

HIV/AIDS-Related Genomics - (CCR)5-Delta32 polymorphism higher in HIV-negative exposed than HIV+ individuals

HIV/AIDS-Related Kaposi Sarcoma - Serologic response against ORF73 differs between HIV patients with/without KS

Healthcare Planning - Surge healthcare planning necessary for future epidemic and terrorist attacks

Hospital-Acquired Infections - Breakthrough for antibiotic drug discovery technology reported

Human Herpesvirus - HHV-8 not associated with angiolymphoid hyperplasia with eosinophilia

Human Papillomavirus - High-throughput PCR chemiluminescent EIA types/quantifies HPV DNA

Immunology - HIV-1 envelope neutralizing antibody 2G12 analyzed

Infectious Disease - HIV/AIDS diagnostic kits bound for Malaysia

Infectious Disease - New institute helps patients and trains professionals in sub-Saharan Africa

Influenza - Employee health education may be the best medicine

Influenza - Specialist suggests pregnant women request flu vaccine to protect mom and baby

Influenza - Tamiflu cited in new antiviral guidelines for preventing, treating influenza

Malaria - Neurocognitive impairment associated with Plasmodium falciparum malaria

Malaria - Polyclonal B-cell activator in Plasmodium falciparum identified

Malaria Therapy - Pyronaridine metabolism characterized in vitro and in vivo

Memingitis - Student hospitalized with meningitis

Meningococcal Disease -  Neisseria meningitides sequence type 66 identified in Poland

Meningococcal Disease - Outbreak in France of N. meningitidis B:15:P1.12 belonging to sequence type 1403

Nosocomial Infection - Quebec hospitals struggle with bacterium outbreak

Obstetrics - Antiretroviral Pregnancy Registry monitoring and analysis plan described

Pathogen Detection - NIH grant awarded to develop phenotype microarray technology

Pneumonia - Cellular and Ab responses against C. pneumoniae may be mutually exclusive

Pneumonia - Nursing home-acquired pneumonia differs from hospital/community-acquired

Proteomics - Insights reported into P. putida KT2440 response to phenol-induced stress

Roundworms -  B. transfuga larva migrans causes fatal neurological disease in Mongolian birds

SARS - SARS antibody test used for serosurveillance

SARS Coronavirus - Medical geography of SARS is explored

Stem Cell Transplantation - HSCT recipients from unrelated donors prone to infectious complications

Tuberculosis -  Mycobacterium tuberculosis NAD kinase reveals a novel fold

Tuberculosis - Prevalence of tuberculosis in foreign-born patients in U.S. increasing

Tuberculosis - TB alliance and U. of Illinois at Chicago collaborate to develop TB macrolides

Vaccine Development - Gene vaccines lead immune response reactions in the desired direction

Vaccine Development - Pharmaceutical device manufacturer announces long-term deal renewal

Varicella-Zoster Virus - Variable patterns of varicella-zoster virus reactivation in Ramsay Hunt syndrome

West Nile Virus - West Nile virus has crossed geographical boundaries

Wound Care - Regulation of skin cell homeostasis may help with wound repair

Wound Care - Silver-infused antibacterial wound dressings for cuts, scrapes, burns introduced

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