Published in Anti-Infectives Week, January 3rd, 2005
"We have developed a receptor-based pharmacophore method which utilizes a collection of protein structures to account for inherent protein flexibility in structure-based drug design.
"Several procedures were systematically evaluated to derive the most general protocol for using multiple protein structures. Most notably, incorporating more protein flexibility improved the performance of the method," scientists writing in the Journal of the American Chemical Society report.
"The pharmacophore models successfully discriminate known...
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