Cytomegalovirus
Initiation of HCMV lytic replication involves transcriptional activation
Published in Anti-Infectives Week, January 24th, 2005
According to recent research published in the Journal of Virology, "Amplification of the human cytomegalovirus (HCMV) lytic origin (oriLyt) in human fibroblasts is dependent upon six core replication proteins and UL84, IE2, and UL36-38.
"Using a telomerase-immortalized human fibroblast cell line (T-HFs), oriLyt-dependent DNA replication no longer required the gene products of UL36-38. To determine the role of IE2 in DNA replication in human fibroblasts, we examined potential IE2-binding sites within HCMV oriLyt."
"We now show that a...
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Source: Anti-Infectives Week (2005-01-24)
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