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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . February 7th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

Anti-Infectives - Daptomycin is effective antibiotic against Gram-positive pathogens

Cystic Fibrosis - Azithromycin shows promising results in early clinical trials

Drug Development - Positive phase IIa data reported for Rambazole and Azoline in fungal infections

Food-Borne Disease - Polymyxin B attenuates Salmonella-induced endotoxin shock

HIV/AIDS Therapy - Dual CCR5/CXCR4 antagonist inhibits HIV-1 replication

Acinetobacter Baumannii - Multiresistant Acinetobacter baumannii clone identified in 24 hospitals

Adverse Drug Reaction - Interaction between valproic acid and carbapenems characterized

Anthrax - Anthrax toxin studied, acid-induced unfolding of domains revealed

Antimicrobials - Evolution of equine infection control programs reviewed

Antimicrobials - Food pathogens and food spoilage organisms inhibited by select raw honeys

Avian Influenza - Bird flu virus confirmed in chickens in Thailand

Biomedical Engineering - Mid-sized software system for lab testing launched by biotechnology company

Business Update - Healthcare consultancy releases analysis of European wound management market

Business Update - Infection control products producer awarded contract by Novation

Business Update - Pharmaceutical company completes level 1 American Depositary Receipts Program

Candida Infection - Very-low-birthweight infants may harbor Candida for a prolonged time period

Clinical Trails - Biopharma company reports encouraging Altastaph phase I/II results in adults

Clinical Trials - Aurexis phase II enrollment complete; Veronate phase III trial tracking well

Collaborations - Companies initiate partnerships to create enhanced monoclonal antibodies

Creutzfeldt-Jakob Disease - Sporadic Creutzfeldt-Jakob disease analyzed, role of plasminogen clarified

Diagnostics - FDA clearance granted for MRSA test

Diagnostics - PCR detects/monitors pathogenic viruses in immunosuppressed pediatric patients

Disease Prevention - Wash hands to help prevent colds and flu

Disease Threat - Boston University researchers did not report illness

Environmental Health - Scientists decipher genome of bacterium that cleans up groundwater pollutants

Epstein-Barr Virus - Epstein-Barr virus detected in lymphoma cells in mantle cell lymphoma patient

Epstein-Barr Virus - Lytic transactivator Rta induces Epstein-Barr virus latent membrane protein 1

Epstein-Barr Virus - Researchers' data advance epstein-barr virus research

Finance - Biotech company announces quarterly dividend for 6% convertible preferred stock

Finance - Company reports Q4 Cubicin revenues of $21.0M, year-end net revenue of $58.6M

Genotype - Clinical and nonclinical Acanthamoeba isolates studied, ATP hydrolysis revealed

HIV/AIDS Associated Disorder - IV immunoglobulin used to treat HIV patient with DILS-associated myositis

HIV/AIDS Drug Analysis - Interaction kinetic data improves HIV-1 protease inhibitor analysis

HIV/AIDS Pathogenesis - HIV nef limits virus-specific CD8 cellular host response

HIV/AIDS Pathogenesis - LEDGF/p75 contains a pair of evolutionarily conserved domains

HIV/AIDS Pathogenesis - Linear HIV viral DNAs containing an extra base are substrates for integration

HIV/AIDS Pathogenesis - Researchers detail new studies and findings in the area of HIV/AIDS pathogenesis

HIV/AIDS Pathogenesis - Target cell Cyclophilin A modulates HIV-1 infectivity

HIV/AIDS Policy - Corporate South Africa slow to response to HIV/AIDS crisis

HIV/AIDS Research - New data illuminates research in HIV/AIDS

HIV/AIDS Research - Recent findings illuminate research in HIV/AIDS

HIV/AIDS Research - Researchers provide details of new studies and findings in the area of HIV/AIDS

HIV/AIDS Research - Researchers report details of new studies and findings in the area of HIV/AIDS

HIV/AIDS Research - TGF-beta inhibits HIV-1 in mammary epithelial cells

HIV/AIDS Therapy - 400 mg indinavir may be efficacious and less toxic than ritonavir and efavirenz

HIV/AIDS Therapy - Amdoxovir + IMPDH inhibitors active against wild-type/drug-resistant HIV-1

HIV/AIDS Therapy - Arylsulfonamides inhibit wild-type and mutant HIV-1 protease

HIV/AIDS Therapy - High-throughput screening identifies NNRTIs with enhanced anti-HIV-1 activity

HIV/AIDS Therapy - Indinavir/ritonavir 667/100 mg toxicity profile may be similar to unboosted IDV

HIV/AIDS Therapy - N-substituted pyrrole derivatives block HIV fusion

HIV/AIDS Therapy - NRTIs cross the placenta by simple diffusion and concentrate in amniotic fluid

HIV/AIDS Therapy - Nucleoside analogues preserve M184V mutation in mixed dual infections

HIV/AIDS Therapy - Polyarginine inhibits gp160 processing by furin and suppresses HIV-1 infection

HIV/AIDS Therapy - Ritonavir has double-boosting function for both lopinavir and saquinavir

HIV/AIDS Therapy - Studies advance knowledge in HIV/AIDS therapy research

HIV/AIDS Therapy - d4T with/without 3TC is an alternative to ZDV for HIV-infected pregnant women

HIV/AIDS Treatment - HIV-focused biopharmaceutical company completes drug studies in Italy and Spain

HIV/AIDS-Associated Infection - Cryptococcal meningitis decreased/cerebral toxoplasmosis increased in HARRT era

HIV/AIDS-Related Drug Interaction - Nevirapine reduces racemic methadone/(R)-methadone levels in HIV infection

HIV/AIDS-Related Neuropathogenesis - Astrocyte dysfunction contributes to HIV Tat neurotoxicity

Health Promotion - Healthy Pride web site launched to address health issues in LBGT community

Helicobacter Pylori -  H. pylori cag pathogenicity island disrupted in majority of patient isolates

Hepatitis C Virus - Hepatitis C is growing danger on Long Island, New York

Herpesvirus - HMGB1 facilitates RTA-mediated viral gene expression in gamma-2 herpesviruses

Herpesvirus - Murine gammaherpesvirus 68 glycoprotein B processing similar to KSHV gB & CMV gB

Immunodeficiency - Antibodies to Haemophilus and Streptococcus in IGIV products detected

Infections -  Angiostrongylus cantonensis infection studied, specific signals identified

Infections -  Rickettsia conorii infection studied, role of early signaling clarified

Influenza - RT-PCR using primers based on HA2 gene detects all 15 HA influenza A subtypes

Influenza Vaccine - Maine lifts restrictions on use of flu vaccine

Influenza Vaccine - Nearly 10,000 doses of flu vaccine available statewide in Arkansas

Influenza Vaccine - New Mexico lifts order restricting flu vaccine

Influenza Vaccine - Restriction on flu shots lifted in Oklahoma

Influenza Vaccine - Vaccine maker takes first steps toward vaccine against deadly flu strain

Listeria Monocytogenes - Mixed-genome DNA microarray identifies L. monocytogenes serotypes & subtypes

Lyme Disease -  Borrelia burgdorferi studied, receptor on Ixodues scapularis revealed

Malaria - Novel malarial protease analyzed, computational predictions reported

Marine Parasite - Real-time PCR detects/quantifies Perkinsus marinus in environmental waters

Mergers & Acquisitions - Infection prevention and decontamination company completes acquisition of Cosmed

Methicillin-Resistant Staphylococcus Aureus - EMSRA strain tracked from one hospital as it spread to surrounding hospitals

Methicillin-Resistant Staphylococcus Aureus - Joint cooperation controls MRSA outbreak involving several hospitals

Mycobacterium Tuberculosis -  Mycobacterium tuberculosis Cameroon family is molecularly characterized

Mycobactetium Brumae -  Mycobactetium brumae caused catheter-related bloodstream infection

Nocardiosis -  Nocardia nova caused sporotrichoid nocardiosis in HIV-infected patient

Norovirus - SDS/EDTA-pretreated chromatography paper strips used for Norovirus sampling

Papillomavirus - Nested PCR with PGMY09/11 and GP5+/6+ primer sets improves HPV DNA detection

Personnel - Anti-infective drug developer names chief medical officer

Pertussis Diagnosis - Cutoff points for antibody levels to pertussis toxin established

Philanthropy - Clinton Foundation and UNICEF launch tsunami water and sanitation fund

Philanthropy - Pharmaceutical company reports on its response to tsunami

Pneumocystis Carinii Therapy - Piperazine-linked bisbenzamidines active against Pneumocystis carinii

Pneumonia - Cytomegalovirus pneumonia not associated with bronchiolitis obliterans syndrome

Pseudomonas Aeruginosa - Carbapenem-resistant Pseudomonas aeruginosa outbreak strain produced VIM-8

SARS Outbreak - Strict infection control is an effective intervention following SARS exposure

Skeletal Tuberculosis - Skeletal tuberculosis may be suspect in cases of long-standing pain and swelling

Tuberculosis - Company announces breakthrough in treatment of TB and MDR-TB

Tuberculosis Therapy - Efficacy of culture media for levofloxacin susceptibility testing determined

Vibrio Parahaemolyticus - KP+/TDH+ environmental V. parahaemolyticus strains isolated

Water Contamination - Household storage practices increase water contamination in India

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