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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . March 7th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

Brucella - Genetic bases of rifampin resistance in Brucella reported

HIV/AIDS Drug Development - Hops Humulus lupulus extract inhibits HIV replication

HIV/AIDS Opportunistic Infection - C-18 mutations critical for CCR5-binding/HIV-1 fusion inhibition

Schistosomiasis Vaccine - Artemether triggers resistance against Schistosoma re-infection

Staphylococcus Vaccine - Glucosamine polysaccharide shows promise for staphylococcal vaccine

Acinetobacter -  Acinetobacter isolates show decrease antibiotic susceptibility over 10+ year

Anti-Infectives - Grapefruit juice enhances antischistosomal effects of artemether

Antibacterial Agents - Positive results reported for Microbisol

Antibiotic Resistance - Penicillin resistance of Streptococcus pneumoniae in Spain decreasing

Antimicrobials - Production of an antifungal molecule by B. licheniformis BC98 optimized

Apoptosis - Histatin analyzed, inhibition of apoptosis in human gingival fibroblasts shown

Bacteriology - Antibacterial effect of wine may be a synergy of organic acids, ethanol, low pH

Bacteriology - Bacteria numbers not correlated to larval lobster mortalities

Bacteriology - Melittin analyzed, hemolytic role of leucine zipper motif revealed

Business & Finance - Antibiotics-focused biopharmaceutical company announces corporate restructuring

Business Update - Infection prevention company's decontamination technology included in report

Cholera Outbreak - Two fowl cholera outbreaks 8-years apart caused by same P. multocida clone

Collaborations - Agreement completed for rights to vaccines

Collaborations - Research collaboration agreement signed

Colon Cancer - Ritonavir may curb colon carcinogenesis via apoptosis/inflammatory modulation

DNA Research -  Escherichia coli RecA complex studied, crystal structures obtained

Dendritic - DC-SIGN tetramers essential for high affinity interactions with HIV

Dengue Outbreak - Integrated therapeutic/public health response controls dengue outbreak

Diagnostics - Real time rtPCR used for patients with severe sepsis

Disease Associations -  Staphylococcus aureus lipoprotein studied, binding behavior shown

Drug Development - International trial of two anti-HIV microbicides begins

Ecology - Lack of permanent pools from intermittent streams reduced algal productivity

Emerging Viral Infections - Emergent viral infections often due to crossing species barrier

Environmental Health - Newly developed drinking-water biofilms favor growth of Nitrosomonas-type AOB

Family Planning - HIV and family planning should be better integrated in Ghana

Food Safety - Genomics provided new insight on microbial food safety

Food-Borne Pathogen -  C. jejuni survives on fresh produce long enough to pose consumer risk

Food-Borne Pathogen - Cold storage of grapefruit decreases survival of salmonellae

Fungal Infection - Phase 3 trial results evaluating anidulafungin for fungal infection announced

Gastroenterology -  Entamoeba histolytica studied, role in erythrocyte digestion clarified

Generic Drugs - Company begins shipping Itraconazole capsules

Generic Drugs - Generic drug-focused company gets U.S. FDA approval of chewable antibiotic tabs

HIV/AIDS Diagnostics - Diagnosis not always self-evident in early stage of HIV-associated wasting

HIV/AIDS Drug Development - Active site conformation used for HIV-1 integrase inhibitor design

HIV/AIDS Drug Development - Thia-DCK analogs inhibit HIV-1

HIV/AIDS Drug Monitoring - Intracellular pharmacology of protease inhibitors improves therapeutic efficacy

HIV/AIDS Healthcare - Over-emphasis on food aid at expense of public health interventions in S Africa

HIV/AIDS Lipodystrophy - IGFBP-3 protease significant regulator of bioactive IGF-I in HIV-lipodystrophy

HIV/AIDS Pathogeneis - HIV-1 envelope facilitates contagious apoptosis

HIV/AIDS Pathogenesis - HIV-1 can dysregulate CD4+ T cells that express CXCR4

HIV/AIDS Pathogenesis - Plasma IL-18 associated with viral load/disease progression in HIV-1-infection

HIV/AIDS Pathogenesis - SOCS box in HIV-1 Vif that mediates its interaction with ElonginC characterized

HIV/AIDS Pathogenesis - T-cell activation leads to poor activation of HIV-1 clade E LTR

HIV/AIDS Pathogenesis - Thioester stability does not correlate significantly with anti-HIV-1 activity

HIV/AIDS Research - APOBEC3B and APOBEC3C are potent inhibitors of SIV replication

HIV/AIDS Research - Cellular adhesion to VCAM-1 mediated by VLA-4 is suppressed after treatment

HIV/AIDS Research - Evans Blue inhibits NF-kappaB-DNA binding

HIV/AIDS Research - HIV LTR-dependent Bax expression selectively induces apoptosis in Tat+ cells

HIV/AIDS Research - SOCS-box phosphorylation regulates assembly of HIV-1 Vif-Cul5 complex

HIV/AIDS Therapy - Difference in median CD4 increase in HIV subtype B vs. non-B after PI therapy

HIV/AIDS Therapy - Drugs to inhibit drug-resistant HIV reverse transcriptases developed

HIV/AIDS Therapy - Entry inhibitor BMS-378806 may have reduced efficacy against non-B HIV-1

HIV/AIDS Therapy - New research in the area of HIV/AIDS therapy detailed

HIV/AIDS Therapy - Studies describe new findings in HIV/AIDS therapy research

HIV/AIDS Treatment - Time delay model shows possible effects of HAART on HIV dynamics

HIV/AIDS Vaccine - Advances in diagnosis and treatment of acute HIV-1 infection reviewed

HIV/AIDS Vaccine - Collaborators expand phase 1 clinical trial of HIV/AIDS vaccine program to India

HIV/AIDS Wasting - HIV-associated wasting exacerbated by reduced food intake/GI dysfunction

HIV/AIDS-Related Aspergillosis - Chest film plus clinical data improves IPA diagnosis in HIV patients

HIV/AIDS-Related Cryptococcosis - HIV infection is the most important risk factor for cryptococcosis

HIV/AIDS-Related Encephalitis - CD163 identifies a unique population of ramified microglia in HIV encephalitis

HIV/AIDS-Related Infection - Strong correlation between eosinophilia and helminthiasis in HIV infection

HTLV-1 Infection - Mathematical model studies the dynamics of HIV-1 infection of CD4+ cells

Hemovigilance - Norway has strict rules regarding hemovigilance for transfusion

Infection Control - Diagnostic testing for etiologic agents of CAP reviewed

Infections -  Bacillus cereus Nhe enterotoxin characterized

Influenza -  Haemophilus influenzae studied, haem-utilization protein identified

Influenza - Flu expanding in Wyoming; more than 500 cases reported

Influenza - Influenza, flu-like illnesses spreading across Tennessee

Kaposi Sarcoma-Associated Herpesvirus - E2-binding C4HC3-type RING domain identified in KSHV K3N-terminal domain

Kaposi Sarcoma-Associated Herpesvirus - New research in the area of kaposi sarcoma-associated herpesvirus detailed

Leishmaniasis Therapy - Effects of renal impairment on antimony pharmacokinetics determined

Malaria - Histidine-rich protein-based malaria drug assay developed, field use reported

Malaria - Incidence data over 30 years reveals trends in Malaria transmission

Malaria - New data illuminates research in malaria

Methicillin-Resistant Staphylococcus Aureus - Gentamicin-susceptible MRSA clone in Rio de Janeiro resembles NY/Japanese clone

Methicillin-Resistant Staphylococcus Aureus - Oils effect antibacterial against epidemic methicillin-resistant S. aureus

Microbicidal Vaginal Gel - Spread of microbicidal vaginal gel dependent on time and volume

Mycoplasma Infection - Bovine pinkeye outbreak associated with mixed mycoplasma infection

Norovirus - Genogroup I/II noroviruses detected in stool samples by real-time RT-PCR

Personnel - Michael W. Aguiar named chief financial officer by biopharmaceutical company

Prodrug - Acyclovir studied, bioavailability and transport in Caco-2 cells revealed

Pulmonary Medicine - The role genetics plays in panbronchiolitis susceptibility is questionable

RNA Research - Potelligent RNAi launched for RNA research

RNA Research - Progress reported on infectious disease program using Neugene antisense drugs

Salmonella Bacteremia - Risk factors identified for developing nontyphoid Salmonella bacteremia

Salmonella Enterica - Virulence gene expression profiles differ with type of S. enterica strain

Salmonellosis - Prolonged incubation period of salmonellosis associated with low bacterial doses

Shellfish Poisoning - Low risk of azaspiracid poisoning from shellfish harvested at Portuguese coast

Surgical Infection - Infected implants studied

Topoisomerase - Topoisomerase terminal domain analyzed, role in catalysis implied

Vibrio Cholerae -  Vibrio cholerae O1 is a resident of Argentinean waters

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