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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . March 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

Anti-Infectives - Novel immunotherapy effective against drug-resistant S. aureus in vitro

Fungal Therapy - Profile of an ideal antifungal presented

HIV/AIDS-Related Dementia - CD14+ macrophage hybrid phenotype circulates in persons with high HIV viral load

Antimicrobials -  Myrothecium cinctum antifungal antibiotic analyzed, properties clarified

Apoptosis - Nature of Anaplasma phagocytophilum neutrophil apoptosis inhibition revealed

Aspergillosis - EIA/qPCR used to diagnose invasive aspergillosis in high-risk patients

Assisted Reproduction - Sperm washing techniques are safe, may address fertility needs of HIV+ men

Avian Influenza - Maine officials prepare for possibility of avian flu

Avian Influenza - Vietnam confirms fourth case of bird flu in a week

HIV/AIDS Research - Findings advance knowledge in HIV/AIDS research

Bacterial Evolution - VNTRs appropriate evolutionary marker for studying bacterial transmission events

Business Update - New plant to provide additional production of Cubicin

Cardiovascular Research - Trials evaluated the effect of antichlamydial antibiotics on secondary CV events

Cervical Cancer - Collaboration will focus on topical anti-HPV treatment

Cryptococcus Diagnostics - RT-PCR assay detects and quantitates Cryptococcus neoformans

Disease Associations -  Streptococcus pneumoniae FtsA protein studied, properties revealed

Disease Associations -  Trypanosoma brucei glycoproteins analyzed, carbohydrate chains revealed

Emerging Disease -  Plesiomonas shigelloides is emerging pathogen with unusual features

Enterotoxigenic Escherichia Coli - Phenotypes determined for ETEC associated with early childhood diarrhea

Enzymology -  Escherichia coli dCTP deaminase studied, behavior determined

Escherichia Coli 0157 Diagnostics - IS1203 PCR rapidly genotypes Shiga toxin-producing Escherichia coli O157

Finance - Pharmaceutical company receives $750,000 equity investment

Finance - Pharmaceutical company reports fourth quarter and full year 2004 results

Finance - Spinoff company Ceptor Corp. completes private offering, becomes independent

Food Safety - Pathogen detection technology developer signs up with Canada lab group

HIV/AIDS Coinfection -  Schistosoma mansoni/HIV-1 coinfection leads to CD4 cell reduction

HIV/AIDS Coinfection - CD4 counts higher in HIV-positive patients infected with Helicobacter pylori

HIV/AIDS Diagnostics - Real-time PCR rapidly discriminates between HIV-2 genotypes A and B

HIV/AIDS Drug Side Effects - Mitochondrial pathogenesis in AIDS due to NRTI-induced DNA polymerase inhibition

HIV/AIDS Encephalitis - Increased FKBP12 may explain vulnerability of basal ganglia to HIV infection

HIV/AIDS Mental Health - Substance P has role in pathophysiology of stress/depression in HIV infection

HIV/AIDS Neurology - CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults

HIV/AIDS Pathogenesis - Acute SIV brain infection leads to upregulation of IL6 ad IFN-regulated genes

HIV/AIDS Pathogenesis - Amyloid precursor protein may facilitate monocyte entry into brain

HIV/AIDS Pathogenesis - Conformational flexibility retained in HIV-1 Rev-RNA complexes

HIV/AIDS Pathogenesis - HIV-specific CTLs from long-term survivors select a unique T cell receptor

HIV/AIDS Pathogenesis - LEDGF/p75 prevents proteasomal degradation of HIV-1 integrase

HIV/AIDS Pathogenesis - MCP-1-2578G allele associated with elevated MCP-1 in cerebrospinal fluid

HIV/AIDS Pathogenesis - Macrophage-secreted MMP 9 is down-regulated following HIV-1 infection

HIV/AIDS Pathogenesis - Soluble toll-like receptor 2 associated with progression of HIV infection

HIV/AIDS Pathogenesis - Ubiquitinated histone H1B is a cofactor to HIV-1 resistance factor

HIV/AIDS Pathogenesis - Urokinase plasminogen activator receptor important in HIV-associated dementia

HIV/AIDS Pediatrics - HAART should be initiated in symptomatic children aged 12 months or older

HIV/AIDS Prevention - Fear of test result and stigmatization are barriers to HIV testing in Bali

HIV/AIDS Research - Data advance knowledge in HIV/AIDS research

HIV/AIDS Research - Tissue culture model analyzes macrophage activation in the brain

HIV/AIDS Therapy - Antiretroviral enfuvirtide is not an inhibitor of p450 cytochrome

HIV/AIDS Therapy - Enfuvirtide improves health-related quality of life in HIV-infected patients

HIV/AIDS Therapy - HAART adherence is the most relevant factor for virological success

HIV/AIDS Therapy - HPLC/UV method suitable for pharmacokinetics of abacavir in plasma

HIV/AIDS Therapy - Molecular basis determined for GLUT4 inhibition by protease inhibitors

HIV/AIDS Therapy - Protease inhibitors impair glucose-stimulated insulin secretion from beta cells

HIV/AIDS Therapy - Studies add new findings to HIV/AIDS therapy body of knowledge

HIV/AIDS-Associated Dementia - Antibody markers identified in HIV-associated dementia

HIV/AIDS-Associated Dementia - Blood-brain barrier compromise has role in pathogenesis of HIV-related dementia

HIV/AIDS-Associated Dementia - HIV dementia risk is associated with apolipoprotein E4 in older persons

HIV/AIDS-Associated Dementia - Oxidative stress markers increased in actively progressive HIV dementia

HIV/AIDS-Associated Infection - Severe respiratory disease necessitating hospitalization decreased in HAART era

HIV/AIDS-Related Dementia - Brain water diffusion contributes to cognitive deficits in HIV infection

HIV/AIDS-Related Dementia - HIV dementia is an evolving disease

HIV/AIDS-Related Lipodystrophy - F-18-fluorodeoxyglucose PET visualizes lipodystrophy in HIV-infected patients

Infant Mortality - Combining interventions into packages could save more lives cost effectively

Influenza Vaccine - Britain stockpiles drugs to combat flu

Influenza Vaccine - British regulators say Chiron free to resume making flu vaccine

Insecticides -  Bacillus thuringiensis cytolytic toxin studied, mechanism of action revealed

Kaposi Sarcoma-Associated Herpesvirus - New research in the area of kaposi sarcoma-associated herpesvirus detailed

Leishmaniasis - Promising visceral leishmaniasis treatments must translate into actual therapy

Leptospirosis - Percutaneous exposure results in laboratory-acquired leptospirosis

Lipoproteins -  Escherichia coli lipoprotein studied, nature of mislocation clarified

Malaria - Malaria morbidity in children increases as transmission intensity decreases

Malaria - Malaria still reduced in areas after withdrawal of deltamethrin spray

Malaria Diagnostics - Four plasmodium species detected in blood by real-time PCR

Malaria Therapy - Researchers provide details of new studies and findings in the area of malaria therapy

Mergers & Acquisitions - Acquisition to result in delivery of bacteriphage therapy to Western world

Mergers & Acquisitions - Dermal Defense acquires marketing rights for antimicrobial hand sanitizer

Microbial Identification - Multispacer typing useful for strain genotyping during outbreaks/bioterrorism

Microbial Resistance - Beta-lactam susceptibilities evaluated against Enterobacteriaceae isolates

Microbial Resistance - In France, ESBL-producing S. enterica strains emerging in chickens & humans

Mosquito-Borne Disease - Aircraft is the main vessel for mosquito entry into New Zealand

Mutagenesis -  Enterococcus faecalis lsa locus studied, differences clarified

Mycobacterial Infection - New mycobacaterial species found in sputum of patient with hemoptoic pneumonia

Mycobacterium Abscessus - Inability to type M. abscessus by PFGE assoc. with single clone of organism

Mycobacterium Xenopi Infection -  Mycobacterium xenopi infection developed following heart transplantation

Natural Products - Bronchitis symptoms reduced by substance in S. African geranium, study shows

Nosocomial Infections - U.S.FDA grants priorty status to drug for serious skin, soft tissue infections

Preventive Medicine - Article examining surgical infection prevention published in journal

Prions - Researchers' data advance prions research

Prison Health - Dallas County, Texas, says it lacks resources to battle jail infections

Protease -  Escherichia coli suicide studied, role of activating peptide revealed

Protein Signals -  Caenorhabditis elegans DAZ-1 studied, roles during oogenesis clarified

Protein Translocation -  Pseudomonas syringae secretion chaperones studied, protective role revealed

Pseudomonas Aeruginosa -  P. aeruginosa LigD analyzed, polymerase function clarified

Pseudomonas Aeruginosa -  Pseudomonas aeruginosa is non-clonal but has an epidemic population

Retroviral Infection - Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML

Reverse Transcriptase - AZT 5'-triphosphate mimics inhibit HIV reverse transcriptase

SARS Coronavirus - Chronological evolution of Ab levels determined after SARS coronavirus infection

SARS Coronavirus - RT-PCR distinguishes SARS coronavirus from other respiratory tract infections

SARS Vaccines - Recent findings illuminate research in SARS vaccines

Signal Transduction -  Escherichia coli signal transduction studied, systems characterized

Smallpox - Imvamune vaccination expected to be effective against smallpox after 3 days

Space Travel - Nanobacterial infections important during space travel

Streptococcal Equi Diagnostics - Multiplex PCR differentiates closely related streptococcal species

Tick-Borne Virus - Tick-borne viruses in Europe are potential agents of bioterrorism

Tuberculosis -  M. tuberculosis lineage with low IS6110 copy numbers clonally expanded

Tuberculosis - Genotypic/phenotypic heterogeneity among M. tuberculosis isolates determined

Vancomycin-Resistant Enterococcus - Esp/vancomycin resistance may contribute to clonal enterococcal dissemination

Vibrio Cholerae - Possible source of V. cholerae outbreak is effluent from ships or poachers

Virology - Findings advance knowledge in virology research

West Nile Virus - West Nile virus is an emerging arbovirus

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