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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . April 18th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

Drug Delivery - Chitosan-alginate multilayer beads provide controlled ampicillin release

Kidney Transplantation - Plasma exchange may prevent graft loss due to atypical HUS

Opportunistic Infections - Guidelines for treating infections in HIV-exposed children released

Varicella-Zoster Virus - Vidarabine has more durable anti-VZV activity than acyclovir in vitro

Allergy & Immunology - Budesonide nasal washing may decrease symptoms in chronic hyperplasic sinusitis

Antimicrobials - Antimicrobial activity of melittin examined, effect of deletion revealed

Antimicrobials - Truncation effects of Helicobacter pylori ribosomal protein L1 revealed

Apoptosis - Macrophage physiology in bacterial clearance studied, Mcl-1 expression defined

Assisted Reproduction - Researchers' findings advance assisted reproduction research

Bacteriology - Data presented on Mycobacterial Cell Wall-DNA Complex

HIV/AIDS Therapy - Researchers publish new studies and findings in the area of HIV/AIDS therapy

Bacteriology - Faster, accurate bacterial detection, removal product line launched

Bacteriology - PSORTdb is protein subcellular localization database for bacteria

Breast Cancer Treatment - Doxycycline enhanced tumor regression activity of cyclophosphamide

Business & Finance - Bioscience company reports second quarter results

Cancer Drugs - Novel cytotoxic cyclic peptide, YM-216391, derived from Streptomyces nobilis

Cryptosporidiosis - Cryptosporidiosis declines after membrane filtration of public water supply

Disease Associations -  Streptococcus pneumoniae adhesion studied, solution structure revealed

Genetics & Genomics - Antibacterial discovery published in journal

HIV/AIDS Biotechnology - LC/MS assay quantities NRTIs in biological matrices

HIV/AIDS Coinfection - Interactions between HIV and herpes viruses occur within the oral mucosa

HIV/AIDS Drug Adherence - Medication adherence training instrument assists persons living with HIV/AIDS

HIV/AIDS Drug Development - Betulinic acid derivatives inhibit HIV-1 fusion/interfere with HIV-1 maturation

HIV/AIDS Drug Development - Cellular deoxyhypusine synthase is a target for antiretroviral therapy

HIV/AIDS Drug Development - Pyridine N-oxide derivatives protects against HIV-induced CD4 cell destruction

HIV/AIDS Drug Resistance - HIV-1 mutations associated with reduced susceptibility identified in Brazil

HIV/AIDS Epidemiology - HLA-A11 associated with CTL response against HIV-1 Nef in exposed persons

HIV/AIDS Healthcare - Case management/shared-care schemes provide integrated care for HIV/AIDS

HIV/AIDS Pathogenesis - Endocytosis contributes to productive HIV entry

HIV/AIDS Pathogenesis - Heterogeneous selective pressures in env gene evolution among HIV-1 subtypes

HIV/AIDS Pathogenesis - Major coreceptors of HIV-2 variants identified from persons with/without viremia

HIV/AIDS Pathogenesis - Myristoyl moiety of HIV Nef involved in regulation of calmodulin interaction

HIV/AIDS Pathogenesis - Recent findings in HIV/AIDS pathogenesis provide new insights

HIV/AIDS Pathogenesis - Rodent cells support key functions of HIV-1 Nef

HIV/AIDS Pathogenesis - VCAM-1 expression on CD8+ cells correlates with enhanced anti-HIV suppression

HIV/AIDS Pathogenesis - Vif defects yield hypermutated genome that integrates but cannot produce progeny

HIV/AIDS Research - Covalent fusions with SlyD or FkpA solubilize retroviral Env proteins

HIV/AIDS Research - Researchers detail new studies and findings in the area of HIV/AIDS

HIV/AIDS Research - SP1 sequence mutation impairs HIV-1 Gag multimerization/membrane-binding

HIV/AIDS Research - Strong genetic signature exists for HIV-1 replication in male genital tract

HIV/AIDS Therapy - CSF HIV is an accessible surrogate for HIV virions in brain

HIV/AIDS Therapy - IL-7 induces latent HIV-1 cellular reservoirs of infected individuals on HAART

HIV/AIDS Therapy - Lymphocyte activation + RT inhibitors protect against retroviral disease

HIV/AIDS Therapy - Researchers provide details of new studies and findings in the area of HIV/AIDS therapy

HIV/AIDS Vaccine - SIV inactivated by N-ethylmaleimide with preservation of functional Env

HIV/AIDS-Related Metabolic Syndrome - Lipid-lowering drugs may cause pharmacokinetic interactions with antiretrovirals

HIV/AIDS-Tuberculosis Coinfection - Fas/Fas-ligand has role in immune modulation and pathogenesis of tuberculosis

HIV/AIDS-Tuberculosis Coinfection - Peripheral lymph node needle-core biopsies diagnose TB in HIV-infected adults

Hepatitis C - Study initiated to evaluate hepatitis C infection post liver transplant

Immune Activation - T cell defects arise from chronic Ag activation leading to rapid CD8+ cell aging

Immunology -  Borrelia burgdorferi analyzed, cross-reactivity of antibodies revealed

Infections -  Leptospira interrogans serovar outer membrane vesicles studied

Inflammation - Influenza infection studied, acute inflammatory state clarified

Interleukin Receptors - Transcriptional regulator examined, influence on kinase 2 promoter clarified

Leishmaniasis - 71 strains from cutaneous leishmaniasis in Tunisia characterized

Megalin - Megalin studied, influence of lipocalin binding demonstrated

Mycobacterium Diagnosis - PCR identifies nontuberculous mycobacteria from paraffin-embedded tissues

Mycobacterium tuberculosis - DC-SIGN differentiates between pathogenic and nonpathogenic mycobacteria

Nocardia brasiliensis - Patients with N. brasiliensis actinomycetoma have type Th2 immune response

Obstetrics - Antibiotics for BV, Trichomonas don't prevent preterm birth in high-risk women

Oncology - Fractionated dosage protocol can promote photodamage to neoplastic tissue

Oncology - New hypothesis on how high disease burden may explain low cancer burden

Oncology - Topical ALA-photodynamic therapy is an effective treatment for Paget disease

Pharmaceutical and Drug Development - pH dependence of binding of drugs to plasma proteins in man reviewed

Philanthropy - Grants support public awareness initiatives for global disease prevention

Physiology -  Escherichia coli ArcA and FNR analyzed, effect of oxygen revealed

Plague -  Yersinia pestis outbreak strains susceptible to antimicrobials

Pneumocystis Infection - General population may be a reservoir of Pneumocystis jirovecii

Product Licensing - Companies ink licensing agreement for HIV integrase inhibitor

Product Licensing - Company licenses compounds for oral diseases to Pacgen

SARS Coronavirus - Researchers' findings advance SARS coronavirus research

SARS Prevention - Findings describe new data in SARS prevention research

Salmonella - Novel PmrA-regulated genes identified in S. enterica Typhimurium

Tuberculosis - Fixed dose combinations for TB helps prevent emergence of drug resistance

Tuberculosis - Proportion method for drug resistant-TB determination not supported by research

Tuberculosis - Pyrosequencing differentiates between M. tuberculosis complex species

Tuberculosis Therapy - Diamine-based antituberculosis drug inhibits intracellular M. tuberculosis

Tuberculosis Therapy - Majority of MDR-TB isolates in Thailand susceptible to second-line drugs

Tuberculosis Treatment - Melatonin prevents free radical/MADD metabolic profiles induced by anti-TB drugs

West Nile Virus - Moroccan West Nile virus isolates related to equine outbreaks in Mediterranean

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