Anti-Infectives Week
Susan Hasty, Publisher
Table of Contents . . . May 9th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Anti-Infectives Week | Other Publications
Drug Development - Febrifugine analogs show promise as antimalarial agents
Drug Development - Novel methylenecyclopropane nucleoside analogs active against herpesviruses
Herpes Simplex Virus - HSV encephalitis during acyclovir therapy reported in premature infant
Nephrotoxicity - Acquired Bartter-like syndrome linked to gentamicin treatment
Peripheral Arterial Occlusive Disease - Anti-C. pneumoniae treatment inhibits PAOD progression
Adenovirus - Adenovirus studied, role of mSur2 in viral replication clarified
Anoplin - Anoplin analyzed, structure and activity explored
Anti-Infectives - Implant biofilm infections treated with low-frequency ultrasound, antibiotics
Anti-Infectives - Ramoplanin is highly active against drug-resistant C. difficile in vitro
Antibacterial Agents - Study shows alcohol-based hand sanitizer reduces respiratory illness
Antibacterial Agents - U.S. FDA approves 0.77% ANDA for OTC topical antifungal ciclopirox cream
Apoptosis - Studies add new findings to apoptosis body of knowledge
Avian Influenza - Avian flu outbreak control integrated human & veterinary health response efforts
Bacteriology - Yersinia species survive and multiply in macrophage phagosomes
Bacteriology - Company expands into human bacterial and viral pathogen detection markets
Bacteriology - Results from clinical studies with investigational antibiotic reported
Bacteriology - Salmonella invasion analyzed, role of fimYZ genes defined
Bioterrorism - Construction company responds to airborne infectious disease isolation needs
Bioterrorism - Multiplexed PCR assay simultaneously detects four biothreat agents
Borrelia - Borrelia burgdorferi factor H-binding protein studied, novel fold revealed
Business Update - Biopharmaceutical company licenses protein variants to Eli Lilly and Company
Business Update - Study on antifungal drug market released
Chlamydia Trachomatis - Rifampin-resistant RNA polymerase mutants remain susceptible to rifalazil
Ciprofloxacin - Staphylococcus aureus fibrnectin adhesions studied, induction clarified
Clostridium Difficile - slpA gene sequenced from C. difficile strains causing outbreaks in Japan
Cytomegalovirus - Murine cytomegalovirus analyzed, genetics of complex formation revealed
Diagnostics - PCR detects pathogenic leptospires earlier than in tissue culture
Diagnostics - Toxigenic culture sensitive for diagnosis of C. difficile-assoc. diarrhea
Disease Associations - Plasmodium sporozoite migration studied, phospholipase involvement shown
Disseminated Tuberculosis - Disseminated TB presented as multiple hepatosplenic microabscesses/pancytopenia
Drug Development - Antibiotic BAL5788 moves into phase III trials
Drug Development - Biopharmaceutical firm granted subsidy for antimicrobial peptide program
Drug Development - Carbamic acid derivative shows promise for hepatic amoebiasis treatment
Drug Development - Developed pyrrole derivatives have antimycobacterial activity
Drug Development - Oligosaccharides weak inhibitors of mycobacterial arabinosyltransferases
Drug Development - Subsidiary receives second year of SBIR biodefense funding
Drug Resistance - Recent findings in drug resistance provide new insights
Encephalomyelitis - Chemokine ligand expression analyzed, effect on encephalomyelitis defined
Enteric Infections - Rifaximin active against enteric infections
Epidemiology - Multiple C. difficile strains in fecal samples limits epidemiology studies
Epstein-Barr Virus - Epstein-Barr virus examined, critical role of BFRF1 revealed
Escherichia Coli - Escherichia coli EspB analyzed, nature of folding revealed
Escherichia Coli - Escherichia coli studied, type III needle complex protein characterized
Escherichia Coli - Enteropathogenic Escherichia coli studied, motility protein identified
Esophageal Perforation - Conservative treatment feasible in children
Finance - Drug company focused on wound healing therapies has record quarterly revenues
Gastroenterology - Lipopolysaccharide induction studied, mitochondrial uncoupling protein recruited
Genetics & Genomics - C. rodentium gene essential for bacterial colonization, cell growth
Genetics & Genomics - Commensal Escherichia coli strain harbors many 'virulence-associated' genes
Genetics & Genomics - O-specific LPS gene cluster identified in CF-associated B. cenocepacia
Genetics & Genomics - Quorum-sensing inhibitors identified by genetic system
HIV/AIDS Drug Development - HIV receptor site interactions with metallocyclams investigated
HIV/AIDS Drug Development - High-throughput modified ELISA screens HIV-1 pg41 fusion inhibitors
HIV/AIDS Drug Development - NNRTI derivatives more potent against HIV-1 than efavirenz
HIV/AIDS Drug Development - Sulfonated naphthyl porphyrins active against HIV-1
HIV/AIDS Drug Development - Trimeric membrane-anchored gp41 inhibits HIV membrane fusion
HIV/AIDS Mental Health - Apathy correlates with cognitive function but not CD4 status in HIV infection
HIV/AIDS Pathogenesis - B30.2(SPRY) domain is the major determinant of anti-HIV-1 potency
HIV/AIDS Pathogenesis - HIV-1 Nef reduces rate of recycling of transferrin receptor to plasma membrane
HIV/AIDS Pathogenesis - HIV-1 Tat stimulates TC assembly through TBP recruitment in absence of TAFs
HIV/AIDS Pathogenesis - HIV-1 Vpr binds to 14-3-3 proteins and facilitates complex formation with Cdc25C
HIV/AIDS Pathogenesis - HIV-1 causes cell death via HIV-1 Vpr derived C terminal peptide
HIV/AIDS Pathogenesis - Interleukin-7 increases HIV-1 LAI-mediated Fas-induced T-cell death
HIV/AIDS Pathogenesis - Preferential apoptosis of HIV-1-specific CD4+ cells in HIV-infected persons
HIV/AIDS Pathogenesis - SATBI interacts with Tat in HIV-1-infected T cells
HIV/AIDS Research - Research in HIV/AIDS provides new insights
HIV/AIDS Therapy - HIV treatment-experienced patients set high standards for therapy success
HIV/AIDS Vaccine - Anti-HIV Abs induced to control viremia via complement-mediated inactivation
Helicobacter Pylori - Helicobacter pylori studied, induction of interleukin-8 secretion clarified
Heparin - Trypanosoma brucei gambiense infection analyzed, effects of heparin revealed
Hepatitis C Therapy - Health Canada grants approval for clinical trial in hepatitis C therapy
Infectious Diseases - Assay distinguishes prion proteins in Creutzfeldt-Jakob disease
Infectious Diseases - Effects of antibiotic studied in CAD patients with C. pneumoniae
Infectious Diseases - Osteopontin studied, modulation of rotavirus diarrhea documented
Infectious Diseases - Reports notes continued increase in sexually transmitted diseases in youth
Kaposi Sarcoma-Associated Herpesvirus - KSHV LANA protects lymphoid cells from p16 INK4A-induced cell cycle arrest
Leishmania - Leishmania HASPB studied, direct mammalian plasma membrane transport revealed
Listeria Diagnostics - Standardization needed for L. monocytogenes detection
Malaria - Malaria parasite examined, surface anchored receptor characterized
Malaria - TOMOCOMD-CARDD approach identifies antimalarial compounds
Malaria Epidemic - Link between climate variability and malaria epidemics still unproven
Mergers & Acquisitions - Getinge acquires life-sciences supplier
Mergers & Acquisitions - Prescription products company and Osmotics Pharma, Inc., announce merger
Mycobacterium Tuberculosis - MTB & M. smegmatis mutants increased beta-lactam antibiotic susceptibility
Mycobacterium Tuberculosis - MTB evades host antimicrobial defenses by inhibiting phagosome maturation
Mycobacterium Tuberculosis - Molecular techniques differentiate MTB strains by genetic polymorphisms
Mycobacterium Tuberculosis - Pathway critical for MTB virulence conserved & functional in M. smegmatis
Mycobacterium Tuberculosis - Peptidoglycan hydrolase Cw1M identified in Mycobacterium tuberculosis
Nosocomial Infections - L. pneumophila persist in water supply regardless of disinfection procedures
Nosocomial Infections - Goods, services provider president speaks on spread of MRSA, other infections
Nosocomial Infections - Nosocomial outbreak-related respiratory pathogens reviewed
Nosocomial Infections - Tracking technology introduced for measuring hospital-acquired infections
Periodontal Disease - P. gingivalis gingipains studied, influence in periodontal disease defined
Personnel - Biopharmaceutical company appoints Harald Labischinski as CEO
Personnel - Device company names Dr. James W. Bracke as COO
Personnel - Quality improvement organization CEO appointed association president
Personnel - Steve Peltzman named CEO by maker of testing devices for disease, drug abuse
Proteomics - Rv3676 protein naturally defective in Mycobacterium bovis BCG strains
Psittacosis Outbreaks - Psittacosis outbreak may be linked to wild birds
Public Health - IT management company expands efforts to automate public health laboratories
Recurrent Urinary Tract Infection - Initiation of two phase II clinical trials of LACTIN-V announced
SARS - Researchers' work adds to SARS body of knowledge
SARS Coronavirus - SARSCoV mutation rates correlate with geographic epidemic characteristics
SARS Coronavirus - Safe & sensitive Spike protein-based IFA detects antibody responses to SARS-CoV
Simian Immunodeficiency Virus - Unliganded/fully glycosylated SIV gp120 structure determined
Staphylococcus Aureus - S. aureus nasal carriage not assoc. with Vitamin D receptor gene mutation
Stroke - FDA approves HYZAAR to help prevent stroke in those with hypertension and LVH
Toxoplasmosis - Biochemical characterization of Toxoplasma gondii peroxiredoxin shown
Transferrin Receptor - Trypanosoma brucei growth differences in different mammalian sera clarified
Tuberculosis - Isoniazid binds to NAT enzyme in mycobacterial cells
Tuberculosis Diagnosis - Culture more sensitive than PCR for extrapulmonary tuberculosis diagnosis
Tuberculosis Drug Development - Quinchamalium majus constituents have potential antitubercular activity
Tuberculosis Vaccine - Prescreening program tested a wide range of tuberculosis vaccines
Typhoid Fever - Salmonella electrophoresis patterns linked to travel analyzed
Vancomycin - Enterococcus gallinarum studied, vanC cluster analyzed
Vancomycin - Vancomycin-resistant Enterococcus faecalis studied, novel peptide shown
Virology - Positive results released in Neugene antisense studies
West Nile Virus - Clinical trial results of rapid assay for West Nile virus infection reported
West Nile Virus - Studies describe new findings in west nile virus research
Wound Dressing - Novel dressing provides long-term ciprofloxacin release
Yersinia - Invasin triggers Rac1-mediated signals enabling Yersinia internalization
Yersinia - LAT/SLP-76 molecules targeted by Yersinia to inhibit T cell activation
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