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Bacteriology

Salmonella invasion analyzed, role of fimYZ genes defined

Published in Anti-Infectives Week, May 9th, 2005

According to a study from the United States, the fimYZ genes regulate Salmonella enterica serovar typhimurium invasion in addition to type 1 fimbrial expression and bacterial motility.

"An important step in S. enterica serovar typhimurium virulence is the ability to invade the intestinal epithelium. The invasion process requires a large number of genes encoded on Salmonella pathogenicity island 1 (SPI-1) at centisome 63 as well as genes located in other positions throughout the chromosome. Expression of the invasive phenotype is tightly regulated by environmental cues that are processed by a complex regulatory scheme."

"A...

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