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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . May 30th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

Antimicrobial Compounds - Parotid secretory protein analyzed, expression in gingival keratinocytes shown

Bone Marrow Transplantation - Treatment may not be needed for children with post-BMT adenovirus infection

Bronchiolitis - Variation in diagnosis and management characterized

Disease Associations - Bacterial pathogens analyzed, secretion translocators and effectors clarified

Nosocomial Infection - Drug resistance of Russian nosocomial S. aureus strains characterized

Anti-Infectives - Reports advance knowledge in anti-infectives research

Antifungal Therapy - Miconazole prolongs QT interval via direct HERG channel blockade

Apoptosis - Apoptosis research company reports preclinical results of animal sepsis study

Aspergillosis - Risk factors for invasive aspergillosis in neutropenic patients identified

Awards - U.S. Army research group awards $4.09 million for development of malaria vaccine

Bacteriology - Interactions may allow Salmonella to successfully evade immune system

Bacteriology - Mouse Paneth cell studied, secretory responses to pathogenic bacteria clarified

Bacteriology - Species exposed to fast growth selection have strongly selected codon usage bias

Bacteriology - Study supports recommendation for prescribing cephalosporin antibiotics

Breast Cancer - HIV Tat targeted into mitochondria of breast cancer cells

Business Update - Antimicrobial skin products maker sells sub-license to N. American distributor

Clostridium Perfringens - Model predicts growth of Clostridium perfringens in pea soup during cooling

Cyclosporiasis - Cyclosporiasis outbreak associated with imported Thai basil

Dicloxacillin - Effect of P-glycoprotein on dicloxacillin pharmacokinetics studied

Disease Associations -  Legionella pneumophila antigens studied, macrophage processing clarified

Disease Associations -  Porphyromonas gingivalis examined, periodontal fimA genotypes clarified

Disease Associations -  Staphylococcus aureus studied, role of prelipoprotein lipidation clarified

Disease Associations - Yersinia outer protein P studied, inhibition of CD8 T cell priming revealed

Drug Resistance - Methicillin-resistant Staphylococcus Aureus infections on the rise

Drug Safety - Drug safety needs outpacing technology solutions, study indicates

Endotoxemia - Endotoxemia examined, cytokine and granulopoiesis responses clarified

Epstein-Barr Virus - Research in epstein-barr virus provides new insights

Escherichia Coli -  Escherichia coli cytolethal toxin studied, carbohydrate binding clarified

Finance - ABELCET maker reports Q3 loss of $4.6 million

Finance - Biopharmaceutical company reports first quarter 2005 financial results

Finance - Biotechnology company reports first quarter 2005 financial results

Finance - Monoclonal antibody-focused biotechnology company reports Q1 2005 results

Finance - Pharmaceutical company reports Q1 2005 financial results

Finance - Pharmaceutical company reports Q1 2005 results, 22% increase in product sales

Finance - Pharmaceutical company reports first quarter financial results

Food Poisoning - Five viruses were detected in foodborne gastroenteritis outbreak

HIV/AIDS Drug Development - Antiviral high throughput approach used to screen HIV-1 inhibitors

HIV/AIDS HAART Compliance - Perceived adverse effects examined as reasons for HAART noncompliance

HIV/AIDS Health Management - HIV/AIDS patients use self-care strategy to effectively manage medications

HIV/AIDS Pathogenesis - Each genomic RNA in HIV-1 heterozygous virus generate new virions

HIV/AIDS Pathogenesis - Findings advance knowledge in HIV/AIDS pathogenesis research

HIV/AIDS Pathogenesis - HIV CCR5/CXCR4 upregulation partially contribute to YY1 downregulation

HIV/AIDS Pathogenesis - HIV-1 CCR5 activation/expression on T cells correlates with disease progression

HIV/AIDS Pathogenesis - HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response

HIV/AIDS Pathogenesis - Single amino acid substitution controls HIV-1 Vif-dependent blocking of APOBEC3G

HIV/AIDS Research - EcoHIV murine model used to study systemic HIV-1 infection

HIV/AIDS Screening - Capillary plasma on filter paper sensitive/specific for pediatric HIV screen

HIV/AIDS Therapy - No "substantial" difference found in antiretroviral therapy benefit by gender

HIV/AIDS Therapy - Research add new data to HIV/AIDS therapy body of knowledge

HIV/AIDS Vaccine Development - Carbohydrate antigens targeted in HIV vaccine development

HIV/AIDS-Related Cryptococcus Infection - PFGE discriminates Cryptococcus neoformans subtypes in HIV infection

HIV/AIDS-Related Infection -  Penicillium marneffei diagnosed in HIV-infected patients in south India

Haemophilus Ducreyi -  Haemophilus ducreyi outer membrane studied, two clonal populations revealed

Hearing Loss - High-frequency pure-tone audiometry detects aminoglycoside ototoxicity

Hematology - Researchers publish new studies and findings in the area of hematology

Infectious Diseases - Data show catheter lock product effective against bloodstream infections

Influenza Outbreak - Prison outbreak from influenza A/Fujian/411/2002(H3N2)-like virus

Kaposi Sarcoma Marker - LANA sensitive/specific KS marker in general and HIV-infected populations

Kidney Transplantation - Research add new data to kidney transplantation body of knowledge

Knee Replacement - Synovectomy, debridement, and continuous irrigation resolves infection

Lactococcus Lactis -  Lactococcus lactis uses MscL as its principal mechanosensitive channel

Lipoproteins - Lipopolysaccharide transfer examined, involvement of lipoproteins clarified

Malaria - Research in malaria provides new insights

Mason-Pfizer Monkey Virus - Integrase of Mason-Pfizer monkey virus cloned and characterized

Medical Devices - Formaldehyde residue remains on plastic equipment after LTSF sterilization

Mergers & Acquisitions - Pharma company acquires partnership interest in Optimer Pharmaceuticals

Mycobacteria - Iron helps regulate isoform expression of catalase-peroxidases in mycobacteria

Mycobacterium Tuberculosis - Binding properties determined for CYP51 from Mycobacterium tuberculosis

Mycobacterium Tuberculosis - Crystal form of MTB low-molecular-weight protein tyrosine phosphatase examined

Mycobacterium Tuberculosis - MTB ESAT-6 gene products modify mycobacteria and immune system interaction

Mycobacterium Tuberculosis - Molecular basis of nitric oxide detoxification mechanism in MTB investigated

Mycobacterium Tuberculosis - Recombinant mtDAHPS from M. tuberculosis is a pentamer in solution

Mycobacterium Tuberculosis - SK1 stimulation by MTB associated with SK1 translocation to phagosome membrane

Norovirus Outbreak - Large-scale gastroenteritis outbreak associated with Norovirus in nursing homes

Norovirus Outbreak - Majority of gastroenteritis outbreaks due to nosocomially-transmitted norovirus

Pediatric Surgery - Fasting does not increase risk of ceftriaxone-associated pseudolithiasis

Personnel - Dr. Gabriel Sosne named to medical and scientific advisory board

Personnel - Henk Kocken, PhD, named VP for quality systems by biopharmaceutical company

Personnel - Pharma appoints T. Jerome Madison to board of directors

Respiratory Diseases - Case reported of pneumonia caused by Ewingella americana

Rhodococcus Equi -  Rhodococcus equi brain abscess diagnosed in patient without HIV

Shiga Toxin - Shiga toxin transport examined, role of luminal chaperone documented

Streptococcus Pneumoniae -  S. pneumoniae StkP/PhpP protein kinase genes operate as a functional pair

Streptococcus Pyogenes -  Streptococcus pyogenes binding studied, role of SpeB protease revealed

Transplant Medicine - Amphotericin B lipid complex effective in treatment of invasive aspergillosis

Tuberculosis - Reports describe recent advances in tuberculosis research

Tuberculosis Vaccine - Successful TB vaccines need to be immunoregulatory rather than Th1-boosting

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