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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . September 12th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

Anti-Infectives - Novel bivalent aminoglycoside antibiotics synthesized

Antimicrobials - Scientists describe the synthesis of carbapenem-based prodrugs

Antimicrobials - Therapeutic potential of antimicrobial peptides reviewed

Infection Control - Handrub reduces nosocomial transmission of drug-resistant bacteria

Prophylactic Antibiotics - Efficacy of oral prophylactic antibiotics in oncology patients examined

Antifungal Drugs - Caspofungin safe and effective antifungal agent

Antimicrobial Drug Resistance - Novel assays identify class C beta-lactamase-producing pathogens

Apoptosis -  Helicobacter pylori-induced macrophage apoptosis studied, c-Myc role defined

Aspergillosis - Aspergillosis outbreak occurred in ostrich flock in Turkey

Baylisascaris Outbreaks -  Baylisascaris larva migrans outbreak occurred in macaque zoo colony in Japan

Business & Finance - Developer of upper respiratory therapies reports Q2 2005 financial results

Business Update - Applied Biosystems inks agreement for advanced food testing systems

Business Update - Company created to produce, market and sell biotech yeast product

Business Update - Life sciences company enters purchasing contract for infection control products

Cancer Research - Company announces publication that pinpoints TAP defect in metastatic carcinomas

Candida Infection - Breakthrough Candida infections occurred in patients receiving voriconazole

Cataract Surgery - Prophylactic gatifloxacin 0.3% ophthalmic solution safe, effective

Chlamydia - Chlamydia inclusion vacuole examined, diacylglycerol accumulation revealed

Chronic Lung Infection - Hypermutation plays key role in P. aeruginosa multiresistance

Colicins - ColE7 analyzed, domain required for import and killing of cells identified

Cryopreservation - Antibiotic carryover may be harmful during heart valve freezing

Drug Development - Marine compounds active against multiple disease categories

Drug Development - U.S. FDA grants approval to market cefuroxime axetil antibiotic tablets in U.S.

Drug Resistance - Antimicrobial resistance found in Shiga toxin-producing E. coli

Enterobacteriaceae - Antibiotic-resistant bacteria in Mhlathuze River poses health risk

Finance - Female condom company reports third quarter ended June 30, 2005 results

Finance - Wound-care supply contract results in strengthening financials

Genetics & Genomics - Latent variable model developed for chemogenomic profiling

HIV/AIDS & Tuberculosis Coinfection - Parotid mycobacteriosis often caused by M. tuberculosis in advanced AIDS

HIV/AIDS Drug Development - HIV-1 protease inhibitor derivatives have antiviral activity

HIV/AIDS Drug Development - Nucleoside analog exerts antiviral effects via mutagenesis of HIV genome

HIV/AIDS Genomics and Genetics - Diversity of thymidine resistance genotypes HIV discussed

HIV/AIDS HAART - HIV protease residue 47 mutations correlate with increasing LPV prescriptions

HIV/AIDS HAART - Racivir safe and effective in HAART-naive HIV-infected patients

HIV/AIDS Pathogenesis - HIV-1 Env-dependent cell-cell fusion modulation related to disease progression

HIV/AIDS Pathogenesis - New data illuminates research in HIV/AIDS pathogenesis

HIV/AIDS Pathogenesis - Oligoclonal T cells infiltrate the brains of children with AIDS

HIV/AIDS Postexposure Prophylaxis - HIV postexposure prophylaxis not routinely offered following sexual assault

HIV/AIDS Research - Biological assay system demonstrates human retroviral protease activity

HIV/AIDS Research - HIV TAT-Hsp70 protects neurons from nitrosative stress and excitotoxicity

HIV/AIDS Research - R5/R5X4/X4 HIV-1 subtype C envelope glycoproteins expressed in insect cells

HIV/AIDS Research - Recent findings illuminate research in HIV/AIDS

HIV/AIDS Risk Behavior - Safe sex practices declined with the introduction of HAART

HIV/AIDS Therapy - Effectiveness of nevirapine studied for prevention of congenital AIDS

HIV/AIDS-Associated Disease - Eye is unlikely to be a site of productive or latent cytomegalovirus persistence

HIV/AIDS-Associated Disease - Poor performance status/HAART absence predicts shorter survival in KSHV/HHV8

HIV/AIDS-Related Dementia - CSF viral load correlates with phase of HIV-associated dementia

Haemophilus Vaccines - Reports describe recent advances in haemophilus vaccines research

Helicobacter Pylori -  Helicobacter pylori phagocytosis studied, actin regulation clarified

Helicobacter Vaccine - Oral vaccine shows promise for eradication of Helicobacter pylori

Hepatitis B Virus Treatment - Lamivudine monotherapy ineffective in children with immune-tolerant HBV

Hepatitis B Virus Treatment - Novel nucleoside reverse transcriptase inhibitor fights HIV and HBV

Hepatitis C Therapy - Phase I clinical trial evaluating GS 9132 for treatment of hepatitis C begins

Hepatitis C Virus Treatment - Caution required with systemic corticosteroids due to adverse effects on HCV

Hepatitis C Virus Treatment - Interferon-related alopecia universalis is benign and reversible

Human Herpesvirus Type 8 - Saliva may be a reservoir for human herpesvirus type 8

Immunotherapy - Metronidazole and TMP/SMX not effective for everyone with B. hominis

Infections - Microbial permeabilization in alveolar fluid studied, surfactant role defined

Infections - Spirochetal infection analyzed, immune responses clarified

Infections - Type III secretion system studied, function of regulatory protein defined

Infectious Disease Surveillance - Infectious disease surveillance in France relies on public health network

Lectins - Pseudomonas lectin binding analyzed, alpha-galactosylated glycans studied

Mergers & Acquisitions - Companies unite to form IDM Pharma

Mergers & Acquisitions - Data management solutions company to acquire Lincoln Technologies

Mergers & Acquisitions - Merger agreement with Pfizer approved by biopharmaceutical company stockholders

Mergers & Acquisitions - Pharmaceutical company acquires controlling interest in antibiotic manufacturer

Mycobacterium Tuberculosis Pathogenesis - Primary type II alveolar cells present microbial Ags to Ag-specific CD4+ cells

Oculopharyngeal Muscular Dystrophy - Doxycycline shows promise for treatment

Outbreak Surveillance - Primary care physicians are timely information source for detecting outbreaks

Pediatric Leukemia - Bloodstream infections occurred in children undergoing acute leukemia treatment

Personnel - Linda Paradiso named VP, clinical and regulatory activities, by biotech company

Poxvirus Vaccine - Inhibition of Abl tyrosine kinases disables poxvirus pathogenesis

SARS Coronavirus - Findings in SARS coronavirus provide new insights

SARS Coronavirus - SARS coronavirus 3a protein induces apoptosis in Vero E6 cells

Salmonella - Salmonella-containing vacuole studied, recycling system interaction detailed

Salmonella Enteritidis Outbreaks - Multiresistant S. enteritidis strains associated with foodborne outbreaks

Sexual & Reproductive Health - Sensitivity of thin film bacterial vaginosis test shown in clinical study

Shigella Dysenteriae Drug Resistance -  S. dysenteriae type 1 Dt66 encodes several drug resistances by chromosome

Simian Immunodeficiency Virus - Simian immunodeficiency virus characterized from a black mangabey

Tuberculosis Control - DOTS improves TB treatment outcomes and service coverage in South Ethiopia

Tuberculosis Drug Development - Oxazolidinones active against M. tuberculosis-infected macrophages

Tuberculosis Epidemiology - Tuberculosis incidence increasing in the European Union

Tuberculosis Vaccine - Antigens with potential in tuberculosis vaccines identified by new technologies

Tuberculosis Vaccine Development - 'Go no-go' decisions in TB vaccine development balances risk/time/resources

Tularemia Outbreaks - Animal outbreaks of Tularemia in France underestimated

Zoonosis - Update on outbreak associated with Streptococcus Suis offered by WHO

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