HIV/AIDS Pathogenesis
HIV-1 gp41 (LM)-M-565 mutation stabilizes the coiled-coil structure
Published in Anti-Infectives Week, October 31st, 2005
According to recent research from Japan, "N-terminal and C-terminal heptad repeats (NHR and CHR) of HIV type I (HIV-1) glycoprotein 41 are known to be regions directly related to cell fusion during virus attack, and their complex core constructs a coiled-coil structure in the fusion process.
"In our recent studies, MT-4/17-3-6, a strain of HIV-1, showed the strong resistance to peptide fusion inhibitors compared with other strains such as MT-4/LAI, L-2 and CU98-26, and had a distinctive (LM)-M-565 mutation in the central region of NHR."
"To investigate the...
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Source: Anti-Infectives Week (2005-10-31)
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