Published in Anti-Infectives Week, October 31st, 2005
There are about 10 million cases of TB globally each year and one in three people are infected with the TB bacterium. BCG is the most widely used vaccine worldwide, but its mechanism of protection is poorly understood. It is thought to prevent progression of infection to active TB but whether it protects against the acquisition of infection itself has not been investigated in humans. The effect of BCG vaccine has been difficult to ascertain because, until recently, the century-old tuberculin skin-prick test (TST)...
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