Published in Anti-Infectives Week, November 7th, 2005
In a recent report, researchers in the United States conducted a study "To gain insight into the role of luxS(Hi) in disease pathogenesis, we inactivated that gene in several nontypeable Hemophilus influenzae isolates with an antibiotic resistance cassette."
D.A. Daines and colleagues, Seattle Biomedical Research Institute, explained, "Gene inactivation was confirmed by PCR and by Southern blot analysis in each strain. Culture filtrates from luxS(Hi) mutants contained a decreased amount of autoinducer-2 (AI-2) activity in comparison to the wild-type isolates using the...
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