HIV/AIDS Pathogenesis
Proliferation-incompetent CD4 cells generated in the presence of chronic Ag exposure
Published in Anti-Infectives Week, February 20th, 2006
"HIV-1 replication is associated with reduced or absent HIV-1-specific CD4+ T cell proliferation and skewing of HIV-1-specific CD4+ T cells toward an IFN-gamma-producing, CCR7- phenotype. The CCR7-T cell population is heterogeneous and can be subdivided based on the expression of CD57," researchers in the United States report.
According to B.E. Palmer and colleagues at the University of Colorado, "Although CD57 expression on CD8+ T cells is associated with proliferation incompetence and replicative senescence, less is known about the function of...
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Source: Anti-Infectives Week (2006-02-20)
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