Influenza Therapy

Study results from St. Jude Children's Research Hospital, Department of Infectious Diseases in the area of influenza therapy published

Published in Anti-Infectives Week, July 9th, 2007

Fresh data on influenza are presented in the report "Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice." According to a study from the United States, "The clinical management of H5N1 influenza virus infection in humans remains unclear. Combination chemotherapy with drugs that target different viral proteins might be more effective than monotherapy."

"BALB/c mice were treated by oral gavage for 5 days with amantadine (1.5, 15 or 30 mg/kg/day) and oseltamivir (1 or 10 mg/kg/day) separately or in combination. Mice were challenged 24 h after initiation of treatment with 10 mouse 50% lethal doses of either amantadine-sensitive (having S31...

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Source: Anti-Infectives Week (2007-07-09)

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