Drug Resistance

Investigators at University of Szeged target drug resistance

Published in Anti-Infectives Week, December 24th, 2007

"Several macrocyclic diterpenes with jatrophane or lathyrane skeletons were isolated from methanol extracts of Hungarian Euphorbia species and evaluated for multidrug resistance (MDR)-reversing activity on a human colon cancer cell line. MDR-reversing activity was tested by using a standard functional assay with Rhodamine 123 as a fluorescent substrate analogue of epirubicin," scientists in Szeged, Hungary report.

"In the model of combination chemotherapy, the interactions between epirubicin and certain resistance modifiers were studied in vitro. Compound 8 proved to be the most active, exhibiting a synergistic interaction. The capacity of the most effective derivative...

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Source: Anti-Infectives Week (2007-12-24)

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