Drug Resistance

Reports from T.J. Zhou and co-researchers add new data to research in drug resistance

Published in Anti-Infectives Week, December 24th, 2007

According to a study from the United States, "Imatinib (Gleevec) is currently the frontline therapy for chronic myeloid leukemia (CML), a disease characterized by the presence of a constitutively activated chimeric tyrosine kinase protein Bcr-Abl. However, drug resistance often occurs at later stage:; of the disease, principally because of the occurrence of mutations in the kinase domain."

"Second generation Bcr-AbI inhibitors, such as dasatinib and nilotinib are capable of inhibiting many imatinib-resistant forms of the kinase but not the form in which threonine is mutated to isoleucine at the gatekeeper position (T315I). In this study, we present the crystal structure...

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Source: Anti-Infectives Week (2007-12-24)

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