Drug Resistance

The structure of resistance

Published in Anti-Infectives Week, March 10th, 2008

A team of scientists from the University Paris Descartes has solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics, according to a report in EMBO reports this month. This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.

Frédéric Dardel and colleagues crystallized both the narrow and broad-spectrum resistance forms of the antibiotic-modifying acetyltransferase enzyme. Their report reveals that the enzyme has a flexible active site that can evolve to accommodate new antibiotics, allowing the bacteria to break them down and render...

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Source: Anti-Infectives Week (2008-03-10)

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