Campylobacter

Scientists at University of Helsinki, Medical Department discuss research in campylobacter

Published in Anti-Infectives Week, December 1st, 2008

"The effects on MIC values and the selection of different base substitutions in the quinolone resistance determining region (QRDR) of gyrA were studied on initially ciprofloxacin-susceptible Campylobacter jejuni strains by challenging them to 0.125mg/L of ciprofloxacin. This ciprofloxacin challenge selected variants with ciprofloxacin MIC levels up to 32mg/L," investigators in Helsinki, Finland report.

"Repeated experiments under identical conditions resulted in different responses in MIC levels and alterations in the QRDR of gyrA. A characteristic outcome to ciprofloxacin challenges was the appearance of double peaks in the sequencing chromatograms of QRDR. This...

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Source: Anti-Infectives Week (2008-12-01)

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