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Acute Myeloid Leukemia

Studies from S.V. Klymenko and co-researchers yield new data on acute myeloid leukemia

Published in Anti-Infectives Week, June 22nd, 2009

"We report on the results of multidrug-resistance transporters (P-glycoprotein, LRP, and MDR1), and apoptosis-related proteins (Fas, Bcl-2, Bax, p53, and Bcl-X-L) expression analysis of 56 acute myeloid leukemia (AML) patients by flow cytometry. Of these, there were 21 persons exposed to ionizing radiation due to the Chornobyl accident with radiation-associated and 35 patients with spontaneous AML," scientists in Melnikova, Ukraine report.

"Leukemic cells in patients with radiation-associated AML more often over-expressed antiapoptotic protein Bcl-2 (12/21 vs. 6/35,p < 0.005) and less often demonstrated expression of Fas receptor (12/21 vs. 30/35, p< 0.05)....

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