Drug Development

Studies from University of Bath provide new data on drug development

Published in Anti-Infectives Week, September 7th, 2009

According to recent research published in the Journal of Medicinal Chemistry, "Twenty-seven dipeptide derivatives of general structure Ac-Xaa-ALA-OR were synthesized as potential prodrugs for 5-aminolaevulinic acid-based photodynamic therapy (ALA-PDT). Xaa is an (x-amino acid, chosen to provide a prodrug with appropriately tailored lipophilicity and water solubility."

"Although no simple correlation is observed between downstream production of protoporphyrin IX (PpIX) in PAM212 keratinocytes and HPLC-derived descriptors of compound lipophilicity, quantification of prodrug uptake reveals that most of the dipeptides are actually more efficiently accumulated than...

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Source: Anti-Infectives Week (2009-09-07)

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