Drug Resistance

Research by O. Simonetti and colleagues in drug resistance provides new insights

Published in Anti-Infectives Week, September 7th, 2009

"An increasing number of antimycotics have become available for the treatment of dermatophytoses; however, there are reports suggesting recalcitrance to therapy or resistance of a dermatophyte against conventional treatment. Lipopeptides represent novel therapeutic drugs with a new mode of action," scientists in Ancona, Italy report.

"The aim of this study was to investigate the in vitro effects of the lipopeptide Pal-Lys-Lys-NH2 (PAL) alone and in combination with standard antifungal agents, such as fluconazole (FLU), itraconazole (ITRA) and terbinafine (TER) against 24 clinical isolates of dermatophytes belonging to four species. A broth microdilution method following...

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Source: Anti-Infectives Week (2009-09-07)

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