Drug Resistance
Findings from Hong Kong Polytechnic University in drug resistance reported
Published in Anti-Infectives Week, November 2nd, 2009
According to recent research published in the Journal of Medicinal Chemistry, "Here we showed that bivalency approach is effective in modulating multidrug resistance protein 1 (MRP1/ABCC1)-mediated doxorubicin (DOX) and etoposide (VP16) resistance in human 2008/MRP1 ovarian carcinoma cells. Flavonoid dimers bearing five or six ethylene glycol (EG) units with 6-methyl (4e, 4f) or 7-methyl (5e, 5f) substitution on the ring A of flavonoid dimers have the highest modulating activity for DOX against MRP1 with an EC50 ranging from 73 to 133 nM."
"At 0.5 mc M, the flavonoid dimer 4e was sufficient to restore DOX accumulation in 2008/MRP1 to parental 2008/P level....
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Source: Anti-Infectives Week (2009-11-02)
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