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NYU Langone Medical Center / New York University School of Medicine

Paradigm changing mechanism is revealed for the control of gene expression in bacteria

Published in Anti-Infectives Week, January 25th, 2010

A new study led by researchers at NYU Langone Medical Center is shedding new light on the action of Rho, a key regulatory protein in E. coli and many other bacteria. The study published in the January 14, 2010 issue of Nature reveals a new paradigm to understand the molecular principles of gene transcription. This work could potentially lead to the development of new types of antibiotics that could target Rho and its crucial functions.

Rho - discovered in 1969 -- is the first transcription termination factor described in bacteria and other organisms. It acts as a red light to gene transcription and is essential for survival in many bacterial species. But the actual...

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