Angiotensins
Studies in the area of angiotensins reported from Sankyo Co., Ltd.
Published in Anti-Infectives Week, March 1st, 2010
According to a study from Hiromachi, Japan, "The inhibitory effect of angiotensin II type 1 receptor blockers (ARBs) on P-glycoprotein (P-gp) was examined to evaluate their clinical drug-drug interaction (DDI) potential. Main methods: We performed an inhibition study on the vectorial transport of digoxin, a typical substrate for P-gp, using a human colonic adenocarcinoma cell line, Caco-2 cells, and verapamil-stimulated ATPase activity using human multidrug resistance 1 (hMDR1)-expressing membrane."
"Key findings: The vectorial transport of digoxin was inhibited by candesartan cilexetil, irbesartan and telmisartan with the IC50 values of 14.7. 34.0 and 2.19 mc M,...
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Source: Anti-Infectives Week (2010-03-01)
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