Published in Anti-Infectives Week, March 22nd, 2010
"In the first step galanthamine 1 was reacted with bis (2-chloroethyl) phosphoramidic dichloride 2/4-nitrophenyl phosphorodichloridate 3 in presence of triethylamine (TEA) in dry tetrahydrofuran (THF) yielded the intermediates 4/5. They were further reacted with various compounds like 2-aminoethanol, ethyleneglycol, ethylenediamine, 2-aminoethanethiol, 2-hydroxy ethanethiol, monopotassium dihydrogenphosphate to obtain the title compounds 6-11 and 12-17," wrote...
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