Immunodeficiency

Osaka University reports research in immunodeficiency

Published in Anti-Infectives Week, May 3rd, 2010

"The anti-retroviral restriction factor TRIM5 alpha contains the RING domain, which is frequently observed in E3 ubiquitin ligases. It was previously proposed that TRIM5 alpha restricts human immunodeficiency virus type 1 (HIV-1) via proteasome-dependent and -independent pathways," scientists in Suita, Japan report.

"Here we examined the effects of RING domain mutations on retrovirus restriction by TRIM5 alpha in various combinations of virus and host species. Simian immunodeficiency virus isolated from macaque (SIVmac) successfully avoided attacks by RING mutants of African green monkey (AGM)-TRIM5 alpha that could still restrict HIV-1. Addition of proteasome inhibitor...

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Source: Anti-Infectives Week (2010-05-03)

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