Published in Anti-Infectives Week, May 3rd, 2010
"Here we examined the effects of RING domain mutations on retrovirus restriction by TRIM5 alpha in various combinations of virus and host species. Simian immunodeficiency virus isolated from macaque (SIVmac) successfully avoided attacks by RING mutants of African green monkey (AGM)-TRIM5 alpha that could still restrict HIV-1. Addition of proteasome inhibitor...
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