Hypersensitivity

Researchers from Arizona State University report on findings in hypersensitivity

Published in Anti-Infectives Week, May 3rd, 2010

According to recent research from the United States, "In Escherichia coli, the TolC-AcrAB complex forms a major antibiotic efflux system with broad substrate specificity. During the complex assembly, the periplasmic helices and bottom turns of TolC are thought to interact with a hairpin helix of AcrA and hairpin loops of AcrB respectively."

"In the present study we show that a four-residue substitution in TolC's turn 1, which connects outer helices 3 and 4 proximal to TolC's periplasmic aperture, confers antibiotic hypersensitivity, without affecting TolC-mediated phage or colicin infection. However, despite the null-like drug sensitivity phenotype, chemical...

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Source: Anti-Infectives Week (2010-05-03)

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