Antimicrobials

Findings from G.B. Trianabaltzer and Co-Authors Provide New Insights into Antimicrobials

Published in Anti-Infectives Week, February 14th, 2011

2011 FEB 14 -- "Influenza viruses (IFVs) frequently achieve resistance to antiviral drugs, necessitating the development of compounds with novel mechanisms of action. DAS181 (Fludase(®)), a sialidase fusion protein, may have a reduced potential for generating drug resistance due to its novel host-targeting mechanism of action," scientists in the United States report.

"IFV strains B/Maryland/1/59 and A/Victoria/3/75 (H3N2) were subjected to > 30 passages under increasing selective pressure with DAS181. The DAS181-selected IFV isolates were characterized in vitro and in mice. Despite extensive passaging, DAS181-selected viruses exhibited a very low...

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Source: Anti-Infectives Week (2011-02-14)

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