Apoptosis

JNK/SAPK required in nitric oxide-induced apoptosis in osteoblasts

Published in Biotech Business Week, January 26th, 2004

JNK/SAPK is required in nitric oxide-induced apoptosis in osteoblasts.

"Nitric oxide (NO) induces apoptosis in human osteoblasts. Treatment with exogenous NO donors, SNAP (S-Nitroso-N-acetylpenicillamine) and SNP (sodium nitroprusside), to MG-63 osteoblasts resulted in apoptotic morphological changes, as shown by a bright blue-fluorescent condensed nuclei and chromatin fragmentation by fluorescence microscope of Hoechst 33258-staining. The activities of caspase-9 and the subsequent caspase-3-like cysteine proteases were increased during NO-induced cell death," scientists in South Korea report.

"Pretreatment with Z-VAD-FMK (a pancaspase inhibitor) or...

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Source: Biotech Business Week (2004-01-26)

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