AIDS/HIV Vaccine

HIV immunization strategies involve adenovirus and poxvirus vaccine vectors

Published in Biotech Business Week, December 20th, 2004

Researchers have developed heterologous human immunodeficiency virus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vaccine vectors.

"We compared the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune responses elicited in nonhuman primates by HIV-1 gag-expressing replication-defective adenovirus serotype 5 (Ad5) or poxvirus vectors, used either alone or in combination with each other. The responses arising from a heterologous Ad5 priming-poxvirus boosting regimen were significantly greater than those elicited by homologous regimens with the individual vectors or by a heterologous poxvirus...

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Source: Biotech Business Week (2004-12-20)

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