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Respiratory Syncytial Virus

Parainfluenza virus expressing fusion protein protects against RSV

Published in Biotech Business Week, December 27th, 2004

Parainfluenza virus type 3 expressing the native or soluble fusion protein of respiratory syncytial virus (RSV) confers protection from RSV infection in African green monkeys.

"Respiratory syncytial virus (RSV) causes respiratory disease in young children, the elderly, and immunocompromised individuals, often resulting in hospitalization and/or death. After more than 40 years of research, a Food and Drug Administration-approved vaccine for RSV is still not available. In this study, a chimeric bovine/human (b/h) parainfluenza virus type 3 (PIV3) expressing the human PIV3 (hPIV3) fusion (F) and hemagglutinin-neuraminidase (HN) proteins from an otherwise bovine PIV3...

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