Cancer Therapy

Inherited traits, tumor mutations affect response to Treatment of ALL

Published in Biotech Business Week, March 28th, 2005

The outcome of chemotherapy treatment for acute lymphoblastic leukemia (ALL) depends not only on the acquired genetic make-up of the leukemic cells, but on genes that children inherit from their parents.

This study, from investigators at St. Jude Children's Research Hospital, is published in the online edition of Blood.

The study provides strong evidence that it might be possible to design ALL treatment based in part on an individual patient's inherited genetic makeup. ALL is the most common tumor in children and affects the cells of the bone marrow. Currently, gene-based individualization of treatments is based only on the genetic mutations...

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Source: Biotech Business Week (2005-03-28)

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