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Chronic Heart Failure

Biopharmaceutical company reports results of treatment for chronic heart failure

Published in Biotech Business Week, July 25th, 2005

Myogen, Inc., (MYOG) announced top line results of ESSENTIAL I & II, the company's two phase 3 trials of enoximone capsules in patients with advanced chronic heart failure (CHF).

The trial results failed to demonstrate a statistically significant benefit for any of the three coprimary endpoints. The trials met the prespecified safety endpoint by demonstrating no significant difference in mortality between the enoximone and placebo groups.

Based on these results, the company will terminate development of enoximone capsules and dedicate all resources to the development of its two other late-stage clinical programs, ambrisentan for the treatment of...

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