Drug Development

Company launches cell-based assay technology for studying cell signaling events

Published in Biotech Business Week, August 22nd, 2005

The new PathHunter cell-based assay platform from DiscoveRx is a screening technology that uses positional complementation in whole-cells to study cell signaling events based on protein translocation and trafficking.

Pathway analysis is critical to understanding how target proteins function in the context of the living cell, and can reveal important information about off-target effects, compound specificity, and cross-reactivity for drug candidates.

Traditional approaches for analysis of protein translocation into the nucleus have either relied upon an indirect approach using reporter gene assays, or have involved the use of GFP or antibodies coupled...

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Source: Biotech Business Week (2005-08-22)

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