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Biotech Business Week

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Cancer Gene Therapy



Tumor cell motility is modulated by MAP4K4 promigratory kinase



May 18th, 2006

According to recent research from the United States, tumor cell motility is modulated by MAP4K4 promigratory kinase.

"Cell motility is a complex biological process, involved in development, inflammation, homeostasis, and pathological processes such as the invasion and metastatic spread of cancer. Here, we describe a genomic screen designed to identify inhibitors of cell migration," wrote C.S. Collins and colleagues, Celgene Signal Research.

"A library of 10,996 small interfering RNAs (targeting 5,234 human genes) was screened for their ability to block the migration of a highly motile ovarian carcinoma cell line, SKOV-3, by using a 384-well...


Source: Biotech Business Week (2006-05-18)

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