Published in Biotech Business Week, July 3rd, 2006
"CF is a fatal genetic disease caused by mutations in cftr, a gene encoding a PKA-regulated Cl-channel. The most common mutation results in a deletion of phenylAla at position 508 (Delta F508-CFTR) that impairs protein folding, trafficking, and channel gating in epithelial cells," wrote F. Vangoor and colleagues, Vertex Pharmaceutical.
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