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CuraGen and TopoTarget expand belinostat (PXD101) clinical trial in cutaneous T cell lymphoma

Published in Biotech Business Week, January 8th, 2007

CuraGen Corporation (CRGN) and TopoTarget A/S announced that the companies have reviewed interim efficacy and safety data from the ongoing open-label trial evaluating belinostat (PXD101) monotherapy for the treatment of cutaneous T-cell lymphoma (CTCL).

The observed preliminary objective response rates have met the predefined criteria for expansion of the CTCL arm of the trial. The predefined criteria in the protocol required at least 2 objective responses be observed in the first 13 patients treated. The trial will now enroll up to a total of 34 patients with CTCL to further evaluate the single agent activity of intravenous belinostat (PXD101) for the treatment of this...

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