Biological Chemistry
Research findings from Amgen, Inc. update understanding of biological chemistry
Published in Biotech Business Week, January 8th, 2007
A report, "Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84," is newly published data in Journal of Biological Chemistry. "Free fatty acids (FFAs) play important physiological roles in many tissues as an energy source and as signaling molecules in various cellular processes. Elevated levels of circulating FFAs are associated with obesity, dyslipidemia, and diabetes," investigators in the United States report.
"Here we show that GPR84, a previously orphan G protein-coupled receptor, functions as a receptor for medium-chain FFAs with carbon chain lengths of 9-14. Medium-chain FFAs elicit calcium mobilization, inhibit 3',5'-cyclic AMP...
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