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Biochemistry
Study results from Millennium Pharmaceuticals, Inc. in the area of biochemistry published
January 29th, 2007
Investigators publish new data in the report "Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop." According to recent research from the United States, "Interleukin-1 stimulation leads to the recruitment of MyD88, interleukin-1 receptor-associated kinase 1 (IRAK-1) and interleukin-1 receptor-associated kinase 4 (IRAK-4) to the IL-1 receptor. The formation of the IL-1 receptor complex triggers a series of IRAK-1 autophosphorylations, which result in activation." "IRAK-4 is upstream of IRAK-1 and may act as IRAK-1 kinase to transmit the signal. To date, there is no upstream kinase reported for IRAK-4; the activation mechanism of IRAK-4...
Source: Biotech Business Week (2007-01-29)
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