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Neurobiology
Studies from Robert S. Dow Neurobiology Laboratories update current data on neurobiology
January 29th, 2007
Current study results from the report, "Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH," have been published. "Acid-sensing ion channels (ASICs), activated by lowering extracellular pH (pH(o)), play an important role in normal synaptic transmission in brain and in the pathology of brain ischemia. Like pH(o), intracellular pH (pH(i)) changes dramatically in both physiological and pathological conditions," researchers in the United States report. "Although it is known that a drop in pH(o) activates the ASICs, it is not clear whether alterations of pH(i) have an effect...
Source: Biotech Business Week (2007-01-29)
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