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Proteomics
Researchers from Amgen, Inc. report on findings in proteomics
January 29th, 2007
Data detailed in "Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry" have been presented. "Metabolic activation of a drug leading to reactive metabolite(s) that can covalently modify proteins is considered an initial step that may lead to drug-induced organ toxicities. Characterization of reactive metabolites is critical to designing new drug candidates with an improved toxicological profile," researchers in the United States report. "High performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) predominates over all analytical tools used for screening and characterization of reactive metabolites. In...
Source: Biotech Business Week (2007-01-29)
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