Investigators at University of California publish new data on drug discovery

Fresh data on drug discovery are presented in the report "2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules." According to a study from the United States, "2-Methoxyestradiol (2ME2), a metabolite of estradiol-17beta, is a novel antimitotic and antiangiogenic drug candidate in phase I and II clinical trials for the treatment of a broad range of tumor types. 2ME2 binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro, suggesting that it may work by interfering with normal microtubule function. However, the role of microtubule depolymerization in its antitumor mechanism of action has been...

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