Biochemistry
Findings from University of Witten, Institute of Physical Biochemistry broaden understanding of biochemistry
Published in Biotech Business Week, February 26th, 2007
Fresh data on biochemistry are presented in the report "How ribosomes make peptide bonds. Ribosomes are molecular machines that synthesize proteins in the cell. Recent biochemical analyses and high-resolution crystal structures of the bacterial ribosome have shown that the active site for the formation of peptide bonds--the peptidyl-transferase center--is composed solely of rRNA," investigators in Herdecke, Germany report.
"Thus, the ribosome is the largest known RNA catalyst and the only natural ribozyme that has a synthetic activity. The ribosome employs entropic catalysis to accelerate peptide-bond formation by positioning substrates, reorganizing water in the active...
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