Neuropharmacology
Research on neuropharmacology reported by scientists at National Institute on Alcohol Abuse and Alcoholism
Published in Biotech Business Week, March 19th, 2007
Research findings, "Antipsychotic clozapine inhibits the function of alpha7-nicotinic acetylcholine receptors," are discussed in a new report. According to recent research from the United States, "The effects of the antipsychotic clozapine on the function of the cloned alpha(7) subunit of the nicotinic acetylcholine (nACh) receptor expressed in Xenopus oocytes was investigated by using the two-electrode voltage-clamp technique. Clozapine reversibly inhibited nicotine (10 microM)-induced currents in a concentration-dependent manner (300 nM to 90 microM), with an IC(50) value of 3.2±0.4 microM."
"The effect of clozapine was not dependent on the membrane potential....
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