Prodrugs
New prodrugs data have been reported by scientists at University of Kuopio, Department of Pharmaceutical Chemistry
Published in Biotech Business Week, April 23rd, 2007
Fresh data on prodrugs are presented in the report "Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality." According to recent research from Kuopio, Finland, "A cyclic phosphate prodrug of a descriptive molecule containing an alcohol functionality was designed, synthesized and characterized in vitro as a cytochrome P450 (CYP) -selective prodrug. To achieve efficient CYP-oxidation and prodrug bioconversion, 1,3-cyclic propyl ester of phosphate was designed to have a C4-aryl substituent and synthesized using phosphorus(III) chemistry. The two-step bioconversion of the cyclic phosphate prodrug was evaluated in vitro using human liver...
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