Bipolar Disorders Therapy
Research in the area of bipolar disorders therapy reported from University of Coimbra
Published in Biotech Business Week, May 28th, 2007
A new study, "Effects of mood stabilizers on the inhibition of adenylate cyclase via dopamine D(2)-like receptors," is now available. "The mood stabilizing drugs lithium, carbamazepine and valproate modulate brain adenosine monophosphate (cAMP) levels, which are assumed to be elevated in bipolar disorder patients. The aim of this work was to investigate how these three mood stabilizing agents affect the regulation of cAMP levels by dopamine D(2)-like receptors in vitro in rat cortical neurons in culture and in vivo in the rat prefrontal cortex," investigators in Coimbra, Portugal report.
"The production of cAMP was measured in the cultured cortical neurons or in...
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