Addiction Medicine
Scripps research study reveals mechanism behind nicotine dependency
Published in Biotech Business Week, October 15th, 2007
The new study reveals that, in rats, chronic nicotine use recruits a major brain stress system, the extrahypothalamic corticotropin releasing factor (CRF) system, which contributes to continued tobacco use by exacerbating anxiety and craving upon withdrawal. The researchers found that administering a compound that blocked the receptors involved in this stress system alleviated withdrawal symptoms.
"We reduced the need to take nicotine by blocking CRF-1 receptors in the brain," says Olivier George, a research associate in the Scripps Research Koob lab who conducted the study with Sandy Ghozland and other colleagues. "We were surprised by the compound's dramatic...
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