Life Sciences

Studies from RIKEN reveal new findings on life sciences

Published in Biotech Business Week, August 11th, 2008

"The spliceosomal protein p14, a component of the SF3b complex in the U2 small nuclear ribonucleoprotein.(snRNP), is essential for the U2 snRNP to recognize the branch site adenosine. The elucidation of the dynamic process of the splicing machinery rearrangement awaited the solution structural information," scientists in Yokohama, Japan report.

"We identified a suitable complex of human p14 and the SF3b155 fragment for the determination of its solution structure by NMR. In addition to the overall structure Of the complex, which was recently reported in a crystallographic study (typical RNA recognition motif fold beta 1-alpha 1-beta 2-beta 3-alpha 2-beta 4 of p14, and...

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Source: Biotech Business Week (2008-08-11)

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